Overview
ZHAW Zurich University of Applied Sciences is exploring advanced analytical methods for monitoring biotechnological cultures and measuring chemical composition in bioreactors. In complex biological matrices, conventional analytical approaches can face limitations due to fluorescence and other interfering factors, making accurate, non-invasive process monitoring challenging.
The research team sought a reliable method to improve specificity and enable more accurate estimation of quality-determining factors, such as product concentration during bioprocessing.
“Timegated® Raman Technology could help us in several ways to better tackle confounding factors that we have to deal with in the complex matrix of biotechnological cultures. Ideally, we hope to achieve greater specificity in tracking selected substances we are interested in during production in bioreactors.”
— Dr. Lukas Neutsch, Head of Bioprocess Technology, ZHAW Wädenswil
Solution
The ZHAW team selected the Timegate PicoRaman® M3 to evaluate the benefits of time-resolved Raman spectroscopy for monitoring and analyzing biotechnological cultures in real time.
The system was chosen for its unique temporal signal control, designed to reduce interference and improve signal specificity in demanding biological samples. In addition to analytical performance, practical factors such as hygienic design, robustness, laboratory mobility, and ease of use supported implementation in a bioprocess environment.
By using Timegated® Raman technology, the team aims to improve non-invasive monitoring and gain more accurate insights into quality-related process parameters inside bioreactors.
Impact
The ZHAW team found the device professional, fast, and flexible, with strong potential for biotechnological applications where conventional Raman methods may be limited by interfering signals.
The collaboration also highlighted future opportunities for development, particularly in software capabilities and connectivity with biological systems to further improve data interpretation and workflow integration.
The team sees significant future potential for Timegated® Raman technology in biotechnological production and broader bio-based industries if interfering factors can be effectively minimized.
“ZHAW is a very active and innovative research organization in the bioprocess field. We can all definitely benefit from this new opening. At Timegate, we are honored about this collaboration with new enthusiastic users of Timegated® Raman Technology.”
— Mari Tenhunen, CEO, Timegate Instruments