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Monitor biologics, bioprocesses, formulations, and pharmaceutical materials with rapid optical analysis that works even in highly complex sample environments.

Real-Time Molecular Insight for Bioprocess Control

Track nutrients, metabolites, viable cells and product quality in real time with Timegated® technology.

Biopharmaceutical and pharmaceutical manufacturing increasingly depends on real-time process understanding to ensure product quality, regulatory compliance and efficient scale-up.

Yet many analytical workflows still rely on offline sampling and delayed laboratory analysis. In complex biological environments, conventional Raman and other optical methods often struggle with fluorescence interference and unstable signal quality.

Timegate brings real-time molecular monitoring directly into biopharma and pharma processes.

Timegated® Raman technology separates fast molecular Raman signals from interfering fluorescence, enabling cleaner molecular data from challenging biological samples.

The result is continuous monitoring potential for nutrients, metabolites, viable cells and critical quality attributes (CQAs) directly from the process, supporting faster decisions, improved process understanding and smarter bioprocess control.

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Why Real-Time Analytics Matters in Biopharma

In modern pharmaceutical manufacturing, timely and reliable data is essential for maintaining control and meeting regulatory expectations. Advanced analytical capabilities enable:

  • Faster deviation detection
    Identify process changes early to prevent out-of-spec conditions.
  • Reduced batch failures
    Improve process control and minimize costly production losses.
  • Improved process robustness
    Gain deeper insight into process variability and stability.
  • Higher yield and efficiency
    Optimize processes to maximize output and resource utilization.
  • Stronger compliance and data confidence
    Support regulatory requirements with consistent, high-quality analytical data.
  • Faster scale-up and tech transfer
    Ensure smoother transition from development to manufacturing with reliable process understanding.

Overcoming analytical challenges in Biopharma

Challenge

Difficulty getting reliable information in-situ

Delayed decisions due to offline analysis

Limited availability for process analytical technology (PAT) applications

Poor performing cultures are not identified until significant time and resources have been invested

Timegate solution

Enables real-time, in situ process monitoring for several CPPs and CQAs simultaneously

Excellent sensitivity in low-concentration and complex systems

Integrates into PAT frameworks via OPC UA for better process control

Automized 96-well plate with 10µL sample volume

Key benefits for Biopharma & Pharma

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Act earlier with confidence

Make informed decisions based on reliable real-time process data

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Improve process understanding

Avoid deviations and product loss for better yield and batch-to-batch consistency.

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Decrease manual sampling

 Minimize offline testing and reduce laboratory workload 

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Accelerate development

Move faster from R&D to sample evaluation and commercial production 

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Reference

Monitoring and analyzing biotechnological cultures

The priority objective for the Bioprocess Technology team of  Zurich University of Applied Sciences (ZHAW) in working with the PicoRaman M3 is monitoring and analyzing biotechnological cultures.

Proven Impact in Biopharmaceutical Applications

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On-Demand Drug Delivery Advances with Time-Gated Raman Spectroscopy

On-demand drug delivery systems are transforming how therapeutics can be administered, enabling precise, localized, and controlled release. In this study, Time-Gated Raman Spectroscopy was used to analyze a novel nanocellulose hydrogel platform, confirming structural stability and supporting the development of light-triggered drug delivery solutions.

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Transforming Biopharmaceutical Manufacturing with Real-Time Process Control

Biopharmaceutical manufacturing is complex, data-intensive, and highly sensitive to process variations. Timegate’s real-time analytical solutions enable continuous monitoring of critical process parameters across upstream and downstream operations, improving process control, product quality, and manufacturing efficiency.

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Ensuring Reliable Blood Analysis with the Finnish Red Cross Blood Service

The Finnish Red Cross Blood Service plays a critical role in supplying safe blood products to hospitals across Finland. Ensuring the quality and integrity of these products requires precise and reliable analytical methods. Timegated® Raman technology enables non-destructive analysis of blood components, supporting quality control and advancing research in transfusion medicine.

Request a sample evaluation with Timegated Raman!

Whether you’re working in life sciences, materials research, or fundamental chemistry, Timegate experts can help optimize your analytical strategies with fluorescence-free Raman insights.