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ZHAW monitoring a bioprocess with the first PicoRaman M3 spectrometer

10:44 Mon 17.10.2022

In May of 2022, the first third-generation instrument PicoRaman M3 was delivered to ZHAW the Zurich University of Applied Sciences. With access to the time-gated Raman technology, the ZHAW team has been able to monitor biotechnological cultures and measure the chemical composition of materials in the bioreactor. ZHAW´s Head of Bioprocess Technology, Dr. Lukas Neutsch shares his insights into their experience with time-gated Raman spectroscopy.



Measuring chemical compositions of materials with time-gated Raman technology


After delivering the spectrometer personally to the ZHAW with our distributor Physical Electronics and the device was successfully installed in the Department of Life Science and Facility Management, the first test phase started immediately.

Shortly later, they were monitoring a bioprocess and measuring the chemical composition of materials with time-gated Raman technology for various applications in biologics - and elsewhere! The ZHAW team felt that Timegate´s support was direct and very customized regarding the installation and furthermore, the communication was friendly and personal.

Headshot of Lukas Neutsch.
Timegated® technology could help us in several ways to better tackle confounding factors that we have to deal with in the complex matrix of biotechnological cultures. Ideally, we hope to achieve greater specificity in tracking selected substances we are interested in during production in bioreactors.           
Dr. Lukas Neutsch, Head of Bioprocess Technology, ZHAW Wädenswil

Monitoring biotechnological cultures with time-gated Raman spectrometer


The most important goal for ZHAW in working with the PicoRaman M3 is monitoring and analyzing biotechnological cultures. The time-resolved technology could offer advantages over currently established methods, especially when it comes to non-invasive, accurate estimation of quality-determining factors such as the concentration of the product formed in the bioreactor.

We chose Timegate´s PicoRaman M3 instrument because of the technical advancement through the temporal control of the signal, which is only available in this device and could help us to better deal with certain interfering factors. In addition to the improved signal specificity mentioned, certain aspects of handling (hygienic design, robustness, mobility in the laboratory) must be given to be able to use the device to its full extent in our field of application.

Read the whole story and find out how Timegate´s CEO Mari Tenhunen commented on this collaboration: Reference case - ZHAW.

Download PicoRaman M3 brochure

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