Timegated® Raman Spectroscopy
In pharmaceutical sciences
Raman spectroscopy has found its way to industrial laboratories and process analytical technologies (PAT) hence becoming a viable tool for a plethora of applications in the pharmaceutical sciences. Raman is a recognized means to analyze non-destructively solid and liquid formulations, phase transitions and polymorphs in all phases of drug discovery, development and large-scale production.
Until now many Raman analyses have been confined by the high fluorescence of pharmaceutical samples. PicoRaman brings the benefits of Raman spectroscopy to a new level by rejecting the fluorescence and enabling a completely new window for the analyses.
Download an application note about the pharmaceutical sciences.
Timegated® Raman Spectroscopy
For biopharmaceutical solutions
Protein- and macromolecule-based drugs (i.e. biopharmaceuticals or biologics) are manufactured using biological-expression entities such as bacterial, mammalian or insect cells. Such conditions impose a significant biochemical and productional complexity for controlling and quantifying the processes and ensuring the efficacy and safety of the macromolecule products.
Raman spectroscopy overcomes many of these difficulties while being a non-contact, robust, insensitive to water, suitable for automation as well as a flexible measurement technique. PicoRaman’s time-resolved detection for fluorescence suppression, advanced pulsed laser and possibility to simultaneously determine the fluorescence lifetimes resolve the current limitations in the research and production of biopharmaceuticals.
Check an application note about the biologic application area.
Timegated® Raman Spectroscopy and Microscopy
For biological solutions
Time-gated Raman, especially when combined with microscopic techniques, provides labelless structural and biochemical information without interference caused by water and without the need for sample preparation. Cell research and microbiology are prominent areas which greatly benefit of these properties; mammalian and plant tissues, (fixed) cells in vitro and biofluids are examples wherein Raman is typically a powerful analytical tool.
Timegate Instruments' new Raman technology also enables non-expert users to produce accurate, high-quality data for analyzing biological materials. With PicoRaman and the Raman microprobe adapter the measurements can be performed in ambient light, in physically and chemically varying environments and without the distraction of fluorescence background signals interference.
Download a Raman Microprobe brochure for more information about the product.
